Abstract
.Abstract: Deficiency of collagen regeneration, denaturalization of fibers, increased melanin synthesis and reactive oxygen species are important factors inducing deterioration of healthy skin function. They induce freckles and de-crease in skin elasticity. Vitamin C, vitamin A and their deriv atives have been used as cosmetic ingredients for im-provement of these problems but they have various problems. We have been developing the various derivatives of these ingredients. In this study, we investigated whitening eff ect of 3-o-cetyl-L-ascorbic acid (VCCE), a new vita-min C derivative. The VCCE inhibited melanogenesis in a dose dependent manner(44 % at 20 µg/mL) and ty-rosinase expression. For 8 weeks, we also investigated skin bri ghtening effect of VCCE on pigmented spots in UV-ir-radiated human skin. In results, VCCE showed a statistically si gnificant skin whitening effect by mechanical and vis-ual evaluation. Taken together, our findings suggest that the VCCE has potential benefits as an active ingredient for whitening cosmetics. Keywords: 3-
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