Abstract
Hypopigmented macules were present in 18 of 23 patients with tuberous sclerosis. The lesions, which averaged 1 to 3 cm. in diameter, were usually oval with irregular margins. One patient also had partial albinism, and 3 patients had hundreds of finely stippled hypopigmented spots on thir legs. Hypopigmented macules are usually present at birth or appear early in the newborn period and are probably the earliest detectable cutaneous sign of tuberous sclerosis. In a control study, none of 55 neurologically handicapped children had white spots. A single hypopigmented macule was found in 1 of 100 neurologically normal children also examined. Hypopigmented macules were present in 18 of 23 patients with tuberous sclerosis. The lesions, which averaged 1 to 3 cm. in diameter, were usually oval with irregular margins. One patient also had partial albinism, and 3 patients had hundreds of finely stippled hypopigmented spots on thir legs. Hypopigmented macules are usually present at birth or appear early in the newborn period and are probably the earliest detectable cutaneous sign of tuberous sclerosis. In a control study, none of 55 neurologically handicapped children had white spots. A single hypopigmented macule was found in 1 of 100 neurologically normal children also examined.
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