Abstract
The genotoxicity of white phosphorus was previously evaluated using the Ames test, which demonstrated the absence of toxicity. However, with all the advantages of this method, the use of the Ames test has some shortfallsin assessing genotoxicity. For this purpose, a series of supplementary tests wereconducted, including the SOS-lux test for DNA damaging activity. In the present work,the SOS-lux test confirmed the genotoxicity of white phosphorus. Based on a review of the literature, our results denote a first report on the genotoxic properties of white phosphorus. Allium test showed the mitotoxic effect of white phosphorus on eukaryotic cells.
Highlights
Our earlier publications [1 – 4] were devoted to the microbiological conversion of white phosphorus to biogenic phosphate
Since higher concentrations of white phosphorus have a detrimental effect on Salmonella, it was difficult to reliably assess the genotoxicity of P4 in this bacterium
It can be assumed that with an increase in DNA concentration, the damaging activity of P4 should only increase
Summary
Our earlier publications [1 – 4] were devoted to the microbiological conversion of white phosphorus to biogenic phosphate. The work performed by our team is the first example of the assimilation of the artificial xenobiotic white phosphorus by the biosphere. Biodegradation sometimes leads to the formation of more toxic substances, A.KA. Some of them exhibit genotoxicity, leading to an increase in the number of mutations and the emergence of neoplastic disorders. The study of biodegradation of xenobiotics should be accompanied by testing for genotoxicity
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