White matter network disorder in mesial temporal epilepsy: An fMRI study

Abstract

Mesial temporal lobe epilepsy (mTLE) has been considered a network disorder disease in which brain regions extending beyond the epileptogenic zones are always affected. However, abnormalities in white matter (WM) functional networks and their associations with widespread network dysfunction are still being identified in mTLE. Accordingly, we investigated the altered functional activities in WM networks in mTLE using fMRI, which has recently been used to probe WM function. We collected resting-state fMRI data from 39 unilateral mTLE patients with hippocampal sclerosis and 29 healthy controls. Eleven WM networks were clustered according to temporal correlation profile. The functional connectivity (FC) of the WM networks were evaluated and compared between the two groups. Furthermore, we assessed the capacity of WM FC for seizure lateralization. According to our analysis, mTLE led to decreased FC within deep WM networks. In addition, the cortical regions involved in seizure propagation and several brain regions displaying interhemispheric disruption showed enhanced functional coupling with deep WM networks. FCs between the ipsilateral deep WM networks and the insula, temporal lobe, and supramarginal gyrus demonstrated positive correlation with seizure frequency. Moreover, the seizure onset zones of 33 patients out of 39 patients could be correctly lateralized. Our findings reveal functional disruptions in WM networks extending to extratemporal regions, supporting the network disorder hypothesis and suggesting that deep WM networks are key network nodes associated with massive dysfunction in mTLE. Moreover, the FC of the WM represents a potentially useful functional imaging measure for the diagnosis of mTLE.