Abstract
Background: Diffusion tensor (DT) magnetic resonance imaging (MRI) provides several quantities with the potential to disclose white matter (WM) microstructure abnormalities. Among these, fractional anisotropy (FA) reflects axonal integrity and fiber organization, mean diffusivity (MD) measures the overall magnitude of diffusion, axial diffusivity (λ||) is associated with fiber density and axon intrinsic characteristics, whereas radial diffusivity (λ┴) reflects the degree of myelination.
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