Abstract
BackgroundThe pathophysiological mechanism of white matter lesions (WML) and dilated Virchow–Robin spaces (DVRS), both frequently encountered in myotonic dystrophy 1 (DM1), is unclear. MethodsWe studied the spatial co-existence of WML and DVRS in 6 DM1 patients with a 1.5T or 3T brain MRI. ResultsCo-localisation with DVRS was found in 86% of the WML. Some WML had a droplet, ovoid, of finger-like aspect following the exactly the orientation of the DVRS. Some WML were linear (indistinguishable from DVRS on T2-weighted imaging) whereas some other WML had a streak- or a dotted-like aspect. ConclusionOur data suggest a pathophysiological relationship between the presence of WML and DVRS in DM1. Some WML might represent, pathologically modified, DVRS.
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