Abstract
A cationic conjugated polyelectrolyte (CPE) PPET3 with a poly(p-phenylene ethynylene terthiophene) backbone and quaternary ammonium side chains was designed and synthesized. It serves as an efficient photosensitizer for photodynamic therapy under white light irradiation and induces cell death through the mitochondrial apoptosis pathway.
Highlights
A cationic conjugated polyelectrolyte (CPE) PPET3 with a poly(p-phenylene ethynylene terthiophene) backbone and quaternary ammonium side chains was designed and synthesized
PPET3 exhibited a wide absorption band located at 350–600 nm with a peak at 450 nm (Fig. S1, Electronic supplementary information (ESI)†), covering the spectral regions ranging from violet, blue, green to yellow and suggesting that the polymer can be excited by broad spectrum white light
Since mitochondria plays a vital role in cell apoptotic pathway, we explored the capability of 1O2 to induce cell apoptosis
Summary
A cationic conjugated polyelectrolyte (CPE) PPET3 with a poly(p-phenylene ethynylene terthiophene) backbone and quaternary ammonium side chains was designed and synthesized. It serves as an efficient photosensitizer for photodynamic therapy under white light irradiation and induces cell death through the mitochondrial apoptosis pathway. Both molar extinction coefficients of PPET3 and PPE were determined to be about 1.5 Â 104 MÀ1 cmÀ1, indicating that the two CPEs have strong light-harvesting capability
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
