Abstract
Although numerous studies explored the consequences of nicotine exposure on cerebellum and on its various layers, little research is focused on nicotine exposure on White core of cerebellum. In the present study, we assessed the effects of long-term nicotine exposure on White matter of cerebellum. Nicotine was administered for 60 days orally via cannula, using dose rate (5mg / day, 10 mg / day) to Male Drukrey rats. The results were compared to control adult rats, given vehicle in identical manner. After 60 days exposure, the cerebellum was removed and processed for histopathologic study. The results showed that long term nicotine treatment regime did result in significant loss of White core of cerebellum. These findings indicated that mature adult cerebellum is susceptible to the damaging effects of nicotine in depleting White core of cerebellum.
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