Abstract
We have studied the stimulation responses of white cells from 71 preoperative patients with primary lung or colorectal cancer and from 34 non-cancerous control patients. The cells were incubated with allogeneic 3MKC1 extracts of lung and colorectal cancers which we had previously shown to induce tumour-specific responses in the LMI Assay and were cultured with PHA. The stimulation observed in response to tumour extracts was infrequent and was not tumour specific; thus, 7 of 71 patients tested with homologous extracts showed a significant cellular response, compared with 4 of 53 patients tested with heterologous extracts. When cells from non-cancer control patients of similar age were tested with these extracts 6 of 51 responses showed significant stimulation. We also sought to determine if pre-incubation with levamisole could enhance the frequency or specificity of cellular responses, but found that levamisole, in a concentration which significantly enhanced cancer patients' cellular responses to PHA, did not augment responses to allogeneic tumour extracts. Possible reasons why allogeneic extracts are ineffective in the stimulation assay are discussed.
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