Abstract
The role of white blood cell (WBC) count in pathogenesis of diabetes, cardiovascular disease, and obesity-related disorders has been reported earlier. Recent studies revealed that higher WBC contributes to atherosclerotic progression and impaired fasting glucose. However, it is unknown whether variations in WBC and haematologic profiles can occur in healthy obese individuals. The aim of this study is to further evaluate the influence of obesity on WBC count, inflammatory biomarkers, and metabolic risk factors in healthy women to establish a relationship among variables analyzed. The sample of the present study consisted of 84 healthy women with mean age of 35.56 +/- 6.83 years. They were categorized into two groups based on their body mass index (BMI): obese group with BMI > 30 kg/m2 and non-obese group with BMI < 30 kg/m2. We evaluated the relationship between WBC and platelet count (PLT) with serum interleukin 6 (IL-6), C-reactive protein (CRP), angiotensin pi (Ang pi), body fat percentage (BF %), waist-circumference (WC), and lipid profile. WBC, PLT, CRP, and IL-6 in obese subjects were significantly higher than in non-obese subjects (p < 0.05). The mean WBC count in obese subjects was 6.4 +/- 0.3 (x10(9)/L) compared to 4.4 +/- 0.3 (x10(9)/L) in non-obese subjects (p = 0.035). WBC correlated with BF% (r = 0.31, p = 0.004), CRP (r = 0.25, P = 0.03), WC (r = 0.22, p = 0.04), angiotensin 11 (r = 0.24, p = 0.03), triglyceride (r = 0.24, p = 0.03), and atherogenic index of plasma (AIP) levels (r = 0.3, p = 0.028) but not with IL-6. Platelet count was also associated with WC and waist-to-hip ratio (p < 0.05). Haemoglobin and haematocrit were in consistent relationship with LDL-cholesterol (p < 0.05). In conclusion, obesity was associated with higher WBC count and inflammatory parameters. There was also a positive relationship between WBC count and several inflammatory and metabolic risk factors in healthy women.
Highlights
Recent epidemiological studies revealed a positive relationship between cardiovascular disease and inflammatory markers [1]
The positive relationship between white blood cell (WBC) count, insulin resistance, hypertension, and cardiovascular disease has been observed in several studies [1,2,3] whereas it is unknown whether these variations can occur in healthy obese individuals
Higher levels of WBC, lymphocytes, granulocytes, platelet count (PLT) and lower levels of haemoglobin (HGB) were observed in obese subjects compared to non-obese subjects
Summary
Recent epidemiological studies revealed a positive relationship between cardiovascular disease and inflammatory markers [1]. White blood cell (WBC) count, as one of the major components of inflammatory process, plays an important role in pathogenesis of insulin resistance and cardiovascular disease [2]. There has been an enormous interest in the identification of the relationship between WBC count and these inflammatory factors in obese persons with higher fat storages, who are at greater risk of hypertension or complicating cardiovascular disorders [3]. No studies have yet evaluated the relationship of cytokines, such as IL-6, CRP, and angiotensin Π, with WBC and haematological parameters in obesity In this case-control study, we investigated the relationship between WBC count, haematological profile, and inflammatory factors, including CRP, IL-6, and angiotensin Π with fat mass, waist-circumference, and metabolic risk factors of cardiovascular disease in women
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