Abstract
Cachexia or wasting syndrome is often seen in cancer patients. Over half of the patients suffer from this condition although the incidence varies from tumor types. Symptoms of cancer cachexia include progressive weight loss, anorexia, depletion of adipose tissues and loss of skeletal muscle mass. Treatment with nutrient supplements or appetite stimulants often fails to reverse these metabolic abnormalities. Thus far, the exact mechanism in which how cancer causes cachexia is poorly understood. One hypothesis is that tumors secrete factors to induce protein degradation in skeletal muscles and enhance lipolysis in adipocyte tissues. Concordantly, early studies have shown that animal models with tumor removal reverse these metabolic symptoms. Thus, there is a mounting interest of identifying these tumor-derived factors, which may aid the development of new therapeutic interventions. Recently, new findings have shed new light into this strenuous area in which parathyroid
Highlights
Cachexia or wasting syndrome is often seen in cancer patients
It appears that white adipose tissue browning is critical in contribution to the adverse effect of cachexia
They demonstrate that adipose tissue browning is mainly caused by chronic inflammation and increased cytokine IL-6
Summary
Cachexia or wasting syndrome is often seen in cancer patients. Over half of the patients suffer from this condition the incidence varies from tumor types. Symptoms of cancer cachexia include progressive weight loss, anorexia, depletion of adipose tissues and loss of skeletal muscle mass. One hypothesis is that tumors secrete factors to induce protein degradation in skeletal muscles and enhance lipolysis in adipocyte tissues. There is a mounting interest of identifying these tumor-derived factors, which may aid the development of new therapeutic interventions.
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