Whipple's intestinal lipodystrophy.

Abstract

Case Reports1 April 1961WHIPPLE'S INTESTINAL LIPODYSTROPHYISRAELI A. JAFFE, M.D.ISRAELI A. JAFFE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-776 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1907 Whipple described a disease in a 36-year-old physician which was characterized by steatorrhea, weakness, loss of weight, anemia, polyarthritis, and cough.1At post-mortem the most striking finding was a massive deposition of fat in the intestinal and mesenteric lymphatic tissues. Whipple named this disease "intestinal lipodystrophy." At this writing, 87 cases have been reported in the world literature, 69 of which fulfill all of the pathologic criteria. In a recent review, Farnan tabulated the salient clinical features in 60 well documented cases, and added seven more from Great Britain.2He found that diarrhea, arthritis, and abdominal pain were...Bibliography1. Whipple GH: A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull. Johns Hopkins Hosp. 18: 382, 1907. Google Scholar2. Farnan P: Whipple's disease. Quart. J. Med. 28: 163, 1959. MedlineGoogle Scholar3. RuffinShingletonBaylinHymansIsleySandersSohmer JMWWGJJCJKAPMF: I131-labeled fat in the study of intestinal absorption. New Engl. J. Med. 255: 594, 1956. CrossrefMedlineGoogle Scholar4. RuffinKeeverChears JMICWC: Use of radioactive labeled lipids in study of intestinal absorption, a clinical appraisal. Med. Clin. N. Amer. 41: 1575, 1957. CrossrefMedlineGoogle Scholar5. BerkowitzSklaroff DD: The use of radioactive fat in the study of absorption in various disease states. Arch. Intern. 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JonesBensonRoque CMJAAL: Whipple's disease; report of a case with special reference to histochemical studies of biopsy material and therapeutic results of corticosteroid therapy. New Engl. J. Med. 248: 665, 1953. CrossrefMedlineGoogle Scholar11. SierackiFine JCG: Whipple's disease—observations on systemic involvement. II. Gross and histologic observations. Arch. Path. 67: 81, 1959. Google Scholar12. Black-Schaffer B: Tinctorial demonstration of glycoprotein in Whipple's disease. Proc. Soc. Exp. Biol. Med. 72: 225, 1949. CrossrefMedlineGoogle Scholar13. Upton AC: Histochemical investigation of the mesenchymal lesions in Whipple's disease. Amer. J. Clin. Path. 22: 755, 1952. CrossrefMedlineGoogle Scholar14. PuiteTesluk RHH: Whipple's disease. Amer. J. Med. 19: 383, 1955. CrossrefMedlineGoogle Scholar15. Sieracki JC: Whipple's disease—observations on systemic involvement. I. Cytologic observations. Arch. Path. 66: 464, 1958. Google Scholar16. BradoffHoffmanDeLucaSpiro MWAVAHM: Intestinal lipodystrophy (Whipple's disease). J. A. M. A. 171: 154, 1959. CrossrefMedlineGoogle Scholar17. Jarcho S: Steatorrhea with unusual intestinal lesions. Bull. Johns Hopkins Hosp. 59: 275, 1936. Google Scholar18. WangJanowitzAdlersberg CIHDD: Intestinal lipodystrophy (Whipple's disease) amenable to corticosteroid therapy. Gastroenterology 30: 475, 1956. CrossrefMedlineGoogle Scholar19. PlummerWeisigerCaravati KBBCM: Successful corticotropin (ACTH) therapy of Whipple's disease refractory to cortisone. Arch. Intern Med. 91: 784, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 12, 1960.Requests for reprints should be addressed to Israeli A. Jaffe, M.D., Fifth Ave. at 106th St., New York 29, N. Y. 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WEINBERGER, M.D., F.A.C.P.The arthritis of Whipple's diseaseThe Arthritis of Whipple's SyndromeWHIPPLE'S DISEASEThe Effect of Antibiotic and Steroid Therapy in Whipple's DiseaseProphylaxis in patients receiving adrenal steroid therapy 1 April 1961Volume 54, Issue 4Page: 776-790KeywordsAnemiaArthritisFatsGratitudeLipodystrophyLymphoid tissuePathogenesisProteinsSteroid therapyWeight loss ePublished: 1 December 2008 Issue Published: 1 April 1961 PDF downloadLoading ...