Abstract
The standard of care for patients with p16-positive oropharyngeal squamous cell carcinoma (OPSCC) is concurrent chemoradiation (CCRT) with high-dose cisplatin (HDC). Malnutrition due to treatment-related odynophagia and nausea is common with this regimen. Gastrostomy tubes (GT) are often used to improve nutrition, yet the optimal timing of GT placement is unclear. Some physicians recommend GT prophylactically (pGT) before or early in treatment in the absence of swallowing impairment. Others recommend expectant management (EM) with reactive GT (rGT) at the onset of swallowing impairment. We hypothesized that certain subsets of patients would benefit from pGT over EM.
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