Abstract
Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers. After a large introduction that summarizes different types of dendrimers that have been compared with PolyAMidoAMine (PAMAM) dendrimers, this review will focus on the properties of positively and negatively charged phosphorhydrazone (PPH) dendrimers, especially in the field of biology, compared with other types of dendrimers, in particular PAMAM dendrimers, as well as polypropyleneimine (PPI), carbosilane, and p-Lysine dendrimers.
Highlights
In this review, in which phosphorhydrazone dendrimers are compared with other types of dendrimers, we will show that the internal structure of dendrimers may be of crucial importance, in particular when considering the biological properties
These functions were first grafted to the surface of a first-generation PPI dendrimer, and both dendrimers were tested against another chronic inflammatory disease, rheumatoid arthritis (RA)
When considering the delivery of siRNA, phosphorhydrazone dendrimers seem more efficient than the PAMAM dendrimers
Summary
PAMAM (PolyAMidoAMine) dendrimers [1,2,3] In addition to this pioneering work, he has recently proposed a new concept for unifying and defining nanoscience, which he has called “CNDPs,” which stands for Critical Nanoscale Design Parameters [4,5]. The comparison has been carried out for catalysis Different generations of both families of dendrimers have been used for the synthesis of gold nanoparticles (about 2 nm diameter in all cases). Generations 1–5 of PAMAM and PPI (called DAB in in this this study) dendrimers have been functionalized by promesogenic units derived from salicylaldimine. Study) dendrimers have been functionalized by promesogenic units derived from salicylaldimine. All these thesedendrimers dendrimers exhibit exhibit liquid liquid crystalline crystalline properties.
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