Abstract
Aim: to evaluate the effect of carvedilol-induced heart rate changes on left ventricular function and physical capacity in heart failure (HF) patients. Material and methods: 96 patients, aged 55 years (SD=8,19), 91 men with symptomatic systolic HF, EF<40% and NYHA class II/III not receiving beta-blockers but an ACEI and diuretic. Depending on changes in heart rate at rest (HRr) from baseline to 3 months after carvedilol treatment two groups were identified: group I – with an early response to beta-blocker (62 patients) and reduction in HR, and group II – with a late response to beta-blocker (34 patients) and unchanged or increased HRr at 3 months.
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