Abstract
The research was to explore whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi (Scutellaria baicalensis) in treating models rats with pelvic inflammation. Twelve model rats were randomized into a Scutellaria baicalensis group and a Scutellaria baicalensis+garlic group with six in each group for pharmacokinetic analysis. Twenty-four rats were randomized into a Scutellaria baicalensis group, a Scutellaria baicalensis+garlic group, a model control group and a normal control group with six rats in each group for detecting the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) with enzyme-linked immunosorbent assay (ELISA). The results showed that in the Scutellaria baicalensis group, the maximum concentration (C(max)) of baicalin, area under the plasma concentration-time curve (AUC) and the time to C(max) (T(max)) were significantly higher and apparent clearance (CL/F) were significantly lower than those of Scutellaria baicalensis+garlic group. The serum levels of TNF-alpha and IL-6 in the Scutellaria baicalensis group were both significantly lower than Scutellaria baicalensis+garlic group. It was then concluded that garlic not only had negative influence on the absorption of active compounds in Scutellaria baicalensis, but decreased the curative effects of Scutellaria baicalensis in treating model rats with pelvic inflammation. Garlic should not be co-administered with Scutellaria baicalensis.
Highlights
Garlic (Allium sativum) is a common ingredient in Chinese cuisine
A recent research on investigating the possible impact of two commonly used herbal medicines on the pharmacokinetics and pharmacodynamics of warfarin found that cranberry significantly increased the area under the international normalized ratio of prothrombin-time curve by 30% when administered with warfarin and they found that co-administration of garlic did not significantly alter warfarin pharmacokinetics or pharmacodynamics (Mohammed et al, 2008)
Our study aimed to explore the effects of garlic on the pharmacokinetics and curative effects of Scutellaria baicalensis in treating model rats with pelvic inflammation
Summary
Garlic (Allium sativum) is a common ingredient in Chinese cuisine. The compounds in garlic have been found to possess beneficial activities for human health (Bocchini et al, 2001). Our study aimed to explore the effects of garlic on the pharmacokinetics and curative effects of Scutellaria baicalensis in treating model rats with pelvic inflammation. By the HPLC analysis, the content of baicalin in the extracts of Scutellaria baicalensis was 104mg/g.
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