Abstract
Sculpting of structure and function of three-dimensional multicellular tissues depend critically on the spatial and temporal coordination of cellular physical properties. Yet the organizational principles that govern these events, and their disruption in disease, remain poorly understood. My lab works on developing new tools to characterize and understand the role of mechanics in biology. In this talk, I will first introduce our recent progress in characterizing cell and ECM mechanics in 3D and in multicellular systems, such as a breast cancer model. Then I will discuss a recent work reporting the crucial role of interfacial curvature on collective cell migration. Finally, I would also like to discuss the impact of cell mechanics on a verity of critical cell biological functions.
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