Abstract
Receptor-ligand interactions are ubiquitous and crucial in physiological functions. Ligand unbinding rates are thought to have complex dependencies on pulling forces but the effects of forces have not been predicted by simulations. Two types of behavior have been observed in complexes under tension via single molecule experiments. Slip bond behavior refers to unbinding rates that increase when higher forces are applied. This dependence on force can be fit to Bell’s model. On the other hand, catch bond behavior refers to unbinding rates which decrease when higher forces are applied until the force is large enough to resume slip bond behavior.Models varying in complexity were used to show these behaviors.
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