Abstract
In April 2024, the Food and Drug Administration provided accelerated approval for Trastuzumab Deruxtecan for adult patients with advanced solid tumors which have positive immunochemical staining (IHC3+) for HER2 expression, including sarcomas. There should be ample consideration prior to utilization of trastuzumab deruxtecan for patients with sarcomas, as HER2 targeted therapy has been ineffective in certain subtypes.
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