Abstract
A mouse model supports the hypothesis that latent Epstein–Barr virus exacerbates the symptoms of rheumatoid arthritis.
Highlights
Related research article Mouat IC, Morse ZJ, Shanina I, Brown KL, Horwitz MS. 2021
Most exposures to Epstein-Barr virus (EBV) occur during childhood or adolescence without leading to rheumatoid arthritis (RA), but the disease tends to appear after patients turn 60
It is hypothesized that EBV latency – a situation in which the virus becomes dormant within the host cell without producing more viruses – may contribute to RA symptoms appearing later in life
Summary
Related research article Mouat IC, Morse ZJ, Shanina I, Brown KL, Horwitz MS. 2021. Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells. eLife 10:e67024. doi: 10.7554/ eLife.67024. Autoimmune diseases, such as systemic lupus erythematosus multiple sclerosis and rheumatoid arthritis, are thought to be triggered by past viral infections (McClain et al, 2005; Mameli et al, 2012; Costenbader and Karlson, 2006). Rheumatoid arthritis (RA) – an inflammatory autoimmune disease that affects the joints – has been associated with Epstein-Barr virus (EBV) infection (Guo et al, 2018; Costenbader and Karlson, 2006).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
