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Abstract
BackgroundNon-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN: The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet.ResultsBifidogenic effect of WBE was evidenced by an induction of both Bifidobacterium animalis and Bifidobacterium pseudolongum in the caecal content. WBE supplementation normalised WD-induced fat-mass expansion, steatosis, hypercholesterolemia, hyperleptinemia, hyperglycemia and hyperinsulinemia reaching the values of control mice. The reduced glucose-dependent insulinotropic polypeptide (GIP) release observed in WD + WBE mice may be a protective mechanism in terms of reducing adipose tissue storage, hepatic steatosis and glucose homoeostasis.ConclusionWe found that WBE completely abolished WD-induced metabolic disorders. Those results might be useful to take into account nutritional advices to treat obesity and related metabolic disorders such as type 2 diabetes, hypercholesterolaemia and fatty liver diseases when obesity was already established.
Highlights
Obesity and related metabolic disorders such as diabetes, cardiovascular diseases and non-alcoholic fatty liver diseases become major health problems in Western countries, while the consumption of cereals has decreased markedly over the last century[1]
After 1 week of acclimatisation, mice were divided into two groups: a control group (CT) fed with a control diet and a group fed with a western diet (WD)
wheat bran extract (WBE) supplementation in the WD diet from d29 until d56 slowed down the body weight gain compared to the WD group (Fig. 1a) independently of the food intake
Summary
Obesity and related metabolic disorders such as diabetes, cardiovascular diseases and non-alcoholic fatty liver diseases become major health problems in Western countries, while the consumption of cereals has decreased markedly over the last century[1]. Gut microbiota is an important factor involved in the control of body weight and metabolic alterations occurring in obesity[6,7]. To date, no study has evaluated the potential effect of AXOS on metabolic disorders in a model of obesity pre-established upon western diet feeding, in relationship with gut microbiota modulation. Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN: The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet
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