Abstract
ScopeIncreasing the intake of satiety‐enhancing food compounds represents a promising strategy for maintaining a healthy body weight. Recently, satiating effects for the capsaicinoid nonivamide have been demonstrated. As various proteins and amino acids have also been demonstrated to decrease energy intake, oral glucose tolerance test (oGTT)‐based bolus interventions of 75 g glucose + 0.15 mg nonivamide (NV control) are tested with/without combination of a wheat protein hydrolysate (WPH: 2 g) and/or l‐arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects.Methods and ResultsCompared to NV control intervention, ARG and WPH + ARG treatment both reduce (p < 0.01) total calorie intake from a standardized breakfast by –5.9 ± 4.15% and –6.07 ± 4.38%, respectively. For the WPH + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by 13C‐Na‐acetate breath test (−2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control. Correlation analysis between plasma serotonin and gastric emptying reveals a significant association after WPH ± ARG intervention (r = –0.396, p = 0.045).ConclusionCombination of WPH and ARG enhances the satiating effect of nonivamide, providing opportunities to optimize satiating food formulations by low amounts of the individual food constituents.
Highlights
Overweight, obesity, and associated diseases represent a rapidly growing problem in worlds’ population, causing burdens to the affected persons and for the health care system.[1]
For fect does not depend on the amount of the wheat protein hydrolysate (WPH) + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by 13C-Na-acetate breath test (−2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control
In comparison to the NV control, ARG and the combination of WPH + ARG decreased the subjective feeling of hunger (ARG Δ: −0.97 ± 0.31, WPH + ARG Δ: −0.57 ± 0.31, p < 0.05) (Figure 2A)
Summary
Overweight, obesity, and associated diseases represent a rapidly growing problem in worlds’ population, causing burdens to the affected persons and for the health care system.[1]. (oGTT)-based bolus interventions of 75 g glucose + 0.15 mg nonivamide (NV sible strategy that is currently in focus of control) are tested with/without combination of a wheat protein hydrolysate research is to develop foods that combine (WPH: 2 g) and/or l-arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects. For fect does not depend on the amount of the WPH + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by 13C-Na-acetate breath test (−2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control. Correlation analysis between a single compound, thereby limiting the risk of side or adverse effects. Such satiating products are thought to limit dissatisfaction during dieting, which often lead to poor compliance and effectiveness
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