Abstract
Atopic diseases have been reported in patients with low gamma globulin levels, associated with demonstrable skin-sensitizing antibodies in some cases. One patient is reported here who lost previous wheal and erythema sensitivity when she developed a severe hypogammaglobulinemia. Typical atopic dermatitis occurred in 4 of 23 boys with congenital, sex-linked, recessive agammaglobulinemia. No wheal and erythema allergy was demontrable in any of these patients. Attempts to induce the development of skin-sensitizing antibodies to an Ascaris extract in 6 congenital agammaglobulinemic patients were uniformly unsuccessful. These patients did, however, all develop delayed sensitivity to the Ascaris.
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