What to do when a child with nephrotic syndrome has a cold? Learning from RCTs

Abstract

Nephrotic syndrome in children is a relapsing condition with a course that frequently lasts for many years. While steroid-sensitive forms rarely, if ever, lead to impairment of kidney function, the protracted use of different forms of immunosuppression to prevent relapses can be associated with significant morbidity. In recent years, substantial progress has been made in optimizing the use of steroid-sparing immunosuppression in patients who relapse frequently or are steroid-dependent. Despite this progress, in case of relapse, glucocorticoids remain the mainstay of treatment.