Abstract
To the Editor. —The fact that cycloplegics may cause a significant elevation in the intraocular pressure of some normal eyes and some eyes with open-angle glaucoma in the absence of angle closure has received further documentation by the careful study reported by L. S. Harris (Cycloplegic-Induced Intraocular Pressure Elevations, Arch Ophthal 79: 242-246 [March] 1968). The effect of 10% phenylephrine, a commonly used mydriatic, upon intraocular pressure is less clearly defined. Several investigators 1-4 have reported phenylephrine has no effect upon intraocular pressure in open-angle glaucoma. Conversely, Lee 5 reported the paradoxical rise of intraocular pressure of some patients with open-angle glaucoma following instillation of 1% epinephrine or 10% phenylephrine. In these cases outflow facility was decreased without gonioscopically visible closure of the anterior chamber angle. In a personal study of 21 patients with open-angle glaucoma under medical treatment (pilocarpine, anticholinesterases, epinephrine bitartrate, and carbonic anhydrase inhibitors, singly or
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