What’s new in the MDS/MPN overlap syndromes

Abstract

The myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPN) category includes a heterogeneous group of diseases characterised by the co-occurrence of clinical and pathologic features of both myelodysplastic and myeloproliferative neoplasms. The recently published International Consensus Classification of myeloid neoplasms revised the list of entities in this category and the criteria for their diagnosis (Arber DA, Orazi A, Hasserjian RP, et al. Blood 2022; 140: 1200–1228). In addition to the presence of increased peripheral blood cell counts as evidence of myeloproliferative features, concomitant cytopenia as evidence of ineffective haematopoiesis is now an explicit requirement to diagnose these diseases.