Abstract

AbstractSince their introduction about ten years ago the rapid methods for sequencing DNA based either on selective chemical degradation1 or primed enzymatic synthesis2 have been subject to a number of modifications and improvements.3, 4 Two recently published papers describe further advances in these technologies: a method for obtaining information about DNA sequences directly from uncloned mammalian genomic DNA5 and a possible first step towards the automation of DNA sequencing6.

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