Abstract
When a positive antibody screen is encountered there are many pathways that can be followed for antibody identification and every laboratory should have a policy outlining its standard procedures. It is important that a systematic approach is taken, both to assigning a specificity (ies) and to excluding all clinically significant antibodies that the patient is capable of making. Several reagent red cell panels may be needed to identify some combinations of antibodies. It is useful to know the ethnic background of the patient because some combinations of phenotypes are found almost exclusively in certain populations. Identification of alloantibody specificity is a process undertaken to enable informed decisions to be made regarding suitable blood for transfusion to a patient. It is important to realize that not all antibodies are clinically significant and antigen‐negative blood is not always needed. When complex mixtures or antibodies to high incidence antigens are present, resolution can be difficult and time‐consuming, thus causing a delay in patient care.
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