Abstract
PurposeThe aim of this study was to determine whether patients with heart failure (HF) have distinct profiles of cognitive impairment. BackgroundCognitive impairment is common in HF. Recent work found three cognitive profiles in HF patients—(1) intact, (2) impaired, and (3) memory-impaired. We examined the reproducibility of these profiles and clarified mechanisms. MethodsHF patients (68.6±9.7years; N=329) completed neuropsychological testing. Composite scores were created for cognitive domains and used to identify clusters via agglomerative-hierarchical cluster analysis. ResultsA 3-cluster solution emerged. Cluster 1 (n=109) had intact cognition. Cluster 2 (n=123) was impaired across all domains. Cluster 3 (n=97) had impaired memory only. Clusters differed in age, race, education, SES, IQ, BMI, and diabetes (ps≤.026) but not in mood, anxiety, cardiovascular, or pulmonary disease (ps≥.118). ConclusionsWe replicated three distinct patterns of cognitive function in persons with HF. These profiles may help providers offer tailored care to patients with different cognitive and clinical needs.
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