Abstract
Ten years ago, Brooks et al1 coined the phrase “reactive airways dysfunction syndrome” (RADS) to denote the development of a persistent asthma-like condition with airway hyperresponsiveness developing in a previously healthy asymptomatic individual within 24 h of a single exposure to concentrated respiratory irritants. Subsequently, Tarlo and Broder2 defined “irritant-induced asthma” (IIA) in similar fashion but accepted the occurrence of multiple exposure incidents before symptom onset. In the ensuing years, no fewer than 80 cases of RADS and IIA have been reported along with estimates of frequency,2–4 pathologic findings,5–10 hypotheses on pathophysiology,10,11 and results of an epidemiologic investigation of a common source outbreak.
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