Abstract
Evidence-Based Answer Fluoroquinolones remain the single best empiric antibiotic treatment for traveler's diarrhea (SOR: C, consensus guideline). Rifaximin appears as effective as ciprofloxacin but is dosed 3 times a day versus twice a day for ciprofloxacin (SOR: B, RCT). Azithromycin is more effective than levofloxacin in areas where common pathogens demonstrate fluoroquinolone resistance, such as Southeast Asia and India (SOR: B, RCT).
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