Abstract
One of the important remaining challenges of HIV research today is ‘functional cure’ of HIV transmission – interventions to keep viral load at a low or undetectable level after interrupting combined antiretroviral treatment (cART). It has been suggested that so-called ‘elite-controllers’ may provide important clues in this investigation. Elite controllers are by definition able to ‘spontaneously’ maintain their viral loads below the clinical level of detection without ever being treated. Throughout recent years reports have emerged on patients who were first treated with cART and who kept control over the virus after treatment interruption. These patients have been called ‘secondary controller’ or ‘posttreatment controllers’ (PTC). This PTC status may provide additional information to develop a functional cure. This article presents recent findings from observational cohorts and analytical treatment interruption (ATI) studies to suggest that they may reveal modifiable factors that count inspire novel treatment strategies.
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