Abstract
EVIDENCE-BASED ANSWER In patients with osteoarthritis of the knee, serial intraarticular (IA) corticosteroid injections given every 3 months do not cause radiographic joint space narrowing at 2 years (SOR: B, single RCT). When single and serial injections are pooled, pain and function is improved in the short term (up to 6 weeks) but not the long term (after 13 weeks) (SOR: A, meta-analysis of RCTs). Single injections maintain symptom improvement up to 24 weeks (SOR: A, meta-analysis of RCTs).
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