Abstract
Aim: This study aims to investigate the effect of BioGlue (BG) in preventing cellular damage due to pressure increase in saphenous vein grafts (SVGs) used in coronary artery surgery.Methods: Twenty volunteers were accepted into this ex vivo study. SVGs were kept in circulation in the cardiopulmonary bypass (CPB) machine for 60 minutes at a pressure of 120 mmHg and a flow rate of 250 ml/min.Results: In the BG treatment group; Type 1 endothelial damage was observed in five samples (25%), Type 2 endothelial damage in nine samples (45%), and Type 3 endothelial damage in two samples (10%). No endothelial damage was observed in 4 samples.Conclusion: It was observed that the application of BG on the saphenous vein graft under high pressure did not cause endothelial damage due to tissue stiffness that developed.
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