Abstract

EVIDENCE-BASED ANSWER Topical salicylic or lactic acid leads to slightly higher clinical cure rates (66% vs 50%) compared with placebo/no treatment for the treatment of plantar warts (SOR: A, meta-analysis of RCTs) and is recommended first-line treatment (SOR: C, expert opinion). Cryotherapy and placebo both have a 25% cure rate (SOR: B, RCT), yet cryotherapy is also recommended as first-line treatment of plantar warts (SOR: C, expert opinion). Combining salicylic acid and cryotherapy does not improve cure rates (SOR: A, meta-analysis of RCTs). Alternative interventions include laser, topical 5-fluorouracil, topical immunotherapy, hyperthermia, dithranol, formaldehyde, glutaraldehyde, photodynamic therapy, and podophyllotoxin (SOR: C, expert opinion).

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