Abstract

The frequency of abnormal radiographic findings, such as osteophytes and intervertebral disc narrowing in the spine of asymptomatic individuals, typifies the inadequacy of plain X-rays to define the causes of low back pain (LBP) in adults. The weak correlation between LBP and plain X-ray findings is not surprising since most mechanical pain is unrelated to conditions, such as fracture or malignancy, that alter skeletal anatomy. A growing body of evidence supports the role of inflammatory cytokines in intervertebral disc disorders associated with LBP.

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