Abstract

Seeing a big broad smile gladdens us, but not when it is on one of our gels. After months of trying, it is clear to us that the answer is right here in this very gel. However, it is hardly convincing evidence since the bands don’t line up nicely and the key lanes are on opposite sides of the gel. Should we cut them together and bend them in silico until every band lines up as our trained eye tells us that they should? These are the kinds of questions researchers often ask themselves when deciding how to select and prepare data for presentation and publication. Field scientists face similar challenges. Should we include data from the day of that unusual weather event, and if so, how and what value does it have? If one of my

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