Abstract
The constant cry of the public and, therefore, the media, continues without causes or cures: "What is new in arthritis therapy?" Well, as a matter of fact, a lot is new that is important. But get this—it is all based on what is old. Let me give you some examples: First of all, there are salicylates; yes, salicylates. They have been with us since time eternal. But now, through new studies and confirmatory endoscopy research currently under way, we can say that nonacetylated salicylates are not only anti-inflammatory, but they significantly bypass the heart of the greatest problem we now face with arthritis therapy, namely, nonsteroidal anti-inflammatory drug (NSAID) gastropathy. 1 When we first discovered that therapy with aspirin and related NSAIDs effectively blocked prostaglandin synthetase, we had anticipated a basis for simplistically understanding the anti-inflammatory effect of these drugs and, hence, a measure of their efficacy. Almost two
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