Abstract
Four international formulations of “Liquid Gaviscon” have been assessed for the strength of the alginate raft formed on reaction with acid and neutralization properties in a modified Rossett and Rice (1954) test. The results from this investigation show that each formulation of “Liquid Gaviscon” possesses markedly different raft strength and neutralization profiles. The inclusion of antacid materials into “Liquid Gaviscon” formulations increases the neutralization capacity within the raft, but decreases the breaking strength and hence the ability of the raft to form a viscous ‘plug’ in the opening of the oesophagus as a barrier to reflux. This suggests that the modes of action may be different even though the trade names of the formulations are the same. This may have clinical consequences when dispensing parallel imports bearing the ‘Gaviscon’ name.
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