Abstract
Epigenetic change refers to a phenotypic alteration
 without permanent genotypic change, which occurs
 through chromatin modification, DNA methylation,
 histone modification, chromatin-regulating proteins
 and non-coding RNAs. Post-transcriptional m6A
 RNA methylation is also a newly described epigenetic
 mechanism and believed to be a new diagnostic
 biomarker and potential therapeutic target. It is a well-
 known fact that epigenetic changes play a significant
 role in the development and progression of several
 nonneoplastic and neoplastic diseases. Therefore,
 epigenetic changes are of value in diagnostic
 and prognostic terms. On the other hand, with the
 development of personalized medicine and targeted
 treatment approaches, treatment strategies targeting
 the epigenetic changes are becoming a promising
 area for many diseases. The aim of this review is
 to provide information about the mechanisms of
 epigenetic changes and their role in the development
 of neoplastic and nonneoplastic diseases, which may
 be helpful for the clinicians and laboratory medicine
 experts for further researchs.
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