What induces colitis? Hydrogen peroxide or peracetic acid

Abstract

We have read the article of Cammarota et al. with great interest [1]. They analyzed a recent and underestimated disinfection complication. The authors suggested that colitis is due to hydrogen peroxide [1]. Coton et al. suggested that acute colitis is directly induced by peracetic acid [2]. In France, we use peracetic acid with acetic acid to wash endoscopes. The constituents of peracetic acid are hydrogen peroxide and acetic acid. As a concentrate, it is corrosive and irritating to the digestive tract. By releasing free oxygen and hydroxyl radicals, peracetic acid decomposes into oxygen, water, and acetic acid [3]. Peracetic acid and hydrogen peroxide are corrosive if not thoroughly rinsed from the endoscope [4]. Inadequate rinsing of endoscopic channels and surfaces with water after immersion in peracetic acid, may result in colitis, presumably caused by direct irritation of the mucosa.