Abstract
AbstractThe mechanism of gastric acid reduction following vagotomy is still unclear: does this reduction result from a decrease in parietal cell mass, or is the reduction just functional? In an attempt to settle the question, we used a litter of puppies, in which rapid multiplication of parietal cells takes place. We performed truncal vagotomy (histologically proven) on 4 puppies, using 3 puppies as a control group. Open gastric biopsies were taken every month from birth uncil 12 months of age. Parietal cells were counted and correlated with age. We found a significant reduction in the parietal cell mass in the vagotomized group during 4 months after delivery. The possible mechanisms explaining this phenomenon, as well as assumed clinical correlation, are discussed.
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