What Happens to Blood Glucose Concentrations After Oral Treatment for Neonatal Hypoglycemia

Abstract

Objective To determine the change in blood glucose concentration after oral treatment of infants with hypoglycemia in the first 48 hours after birth. Study design We analyzed data from 227 infants with hypoglycemia (blood glucose Results The overall mean increase in blood glucose concentration was 11.7 mg/dL (95% CI 10.4-12.8). The increase was greater after buccal dextrose gel than after placebo gel (+3.0 mg/dL; 95% CI 0.7-5.3; P = .01) and greater after infant formula than after other feedings (+3.8 mg/dL; 95% CI 0.8-6.7; P = .01). The increase in blood glucose concentration was not affected by breast feeding (+2.0 mg/dL; 95% CI −0.3 to 44.2; P = .09) or expressed breast milk (−1.4 mg/dL; 95% CI −3.7 to 0.9; P = .25). However, breast feeding was associated with reduced requirement for repeat gel treatment (OR = 0.52; 95% CI 0.28-0.94; P = .03). Conclusions Treatment of infants with hypoglycemia with dextrose gel or formula is associated with increased blood glucose concentration and breast feeding with reduced need for further treatment. Dextrose gel and breast feeding should be considered for first-line oral treatment of infants with hypoglycemia.