Abstract
aDepartment of Psychiatry, Massachusetts General Hospital, Boston bHarvard Medical School, Boston, Massachusetts. *Corresponding author: Andrew A. Nierenberg, MD, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114 (anierenberg@mgh.harvard.edu). J Clin Psychiatry 2015;76(9):e1161–e1163 dx.doi.org/10.4088/JCP.14com09596 © Copyright 2015 Physicians Postgraduate Press, Inc. B ipolar disorder presents a substantial burden to patients and their loved ones because of its recurrent nature, persistent symptoms, and associated comorbid conditions.1 The first episode occurs most frequently before the age of 25 years and is among the top 10 causes of disability-adjusted life years among youth worldwide.2,3 With a population estimate of 74 million youth in the United States (www. childstats.gov), about 3%4 or 2.2 million will meet criteria for bipolar disorder, in sharp contrast to about 15,800 cases of childhood cancer (www.cancer.gov; a ratio of about 140:1). If the diagnosis is expanded to those who have a bipolar spectrum, the numbers of those affected double.
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