What factors impact the treatment outcomes of laparoscopic adrenalectomy in patients with functioning adrenal gland tumors?

Abstract

IntroductionLaparoscopic adrenalectomy is currently considered a standard treatment for both functional and non-hormonal benign adrenal tumors. However, further studies are required to evaluate the factors that predict treatment outcomes in cases in which laparoscopic adrenalectomy is performed. Materials and methodsThis was a cross-sectional study conducted between 2011 and 2017. The inclusion criteria were a diagnosis of functioning adrenal gland tumors and having undergone transperitoneal laparoscopic adrenalectomy. Important factors affecting the outcomes of treatment were analyzed. ResultsThere were 68 patients enrolled in this study. Participants were divided into two groups based on whether they had cured or uncured hypertension. The median ages in the cured and uncured groups were 41.0 and 54.0 years, respectively (p-value 0.001). The mean tumor size was 20 mm in the cured group and 15 mm in the uncured group. Patients in the cured group experienced a median of 20 ml of blood loss in both groups. Average operating times were 95 and 85 min, respectively. Only two factors were independently associated with uncured hypertension: age and preoperative systolic blood pressure, with adjusted odds ratios (95% confidence interval) of 1.11 (1.03, 1.17) and 1.03 (1.01, 1.07), respectively. ConclusionPredictors for unsuccessful of treatment in patients who underwent laparoscopic adrenalectomy were older age at the time of the operation and preoperative systemic blood pressure.