What evidence is there that adjustment for adult height influences the relationship between birth weight and blood pressure?

Abstract

Background: The inverse association between birth weight and blood pressure may partly be the result of inappropriate adjustment for adult body size, but it remains unclear whether adjustment for adult height elicits this effect.Aim: The study investigated the impact of adjustment for adult height on the relationship between birth weight and blood pressure.Methods: A systematic search of Medline® from 1996 to 2006 was conducted using the terms ‘birth weight’, ‘blood pressure’ and ‘hypertension’, and any papers containing linear regression analyses of blood pressure on birth weight for populations with an average age of 25+ were eligible for inclusion in comparative meta-analyses.Results: None of the 30 studies identified had published regression coefficients for blood pressure on birth weight before and after adjustment for adult height, and only two studies were found to adjust for adult height at all. Data from these studies were obtained, and it was found that adjustment for height made the association between birth weight and systolic blood pressure (SBP) more negative in one study but less negative in the other. When compared with meta-analyses of comparable models, it was found that both studies were substantially different from the combined estimate of the relationship between birth weight and SBP.Conclusions: Both the differences between the two selected studies and their differences from the combined estimates obtained by meta-analysis are likely to be due to differences in the age of the participants. The relationship between birth weight and SBP tended to become more strongly inverse in studies with older participants. Additionally, the correlations between height and SBP were found to change from positive to negative with increasing age, which explained the differential impact of adjustment for height in the two selected studies. It therefore appears that adjustment for height may have little effect for older participants, but more so for younger participants.