Abstract
ABNORMAL LIPOPROTEIN(A) LEVELS Lp(a) levels vary markedly between subjects and population. In the Copenhagen General Population Study, a typical skewed plasma Lp(a) level distribution was shown, with 80% of the population having levels below 50 mg/dL, and only 20% of the population having levels in the 50–200 mg/dL range [10]. Thus, Lp(a) levels > 50 mg/dL, corresponding to the > 80th percentile, are considered abnormal and a constitute a clinical biomarker of an increased CVD risk. Lowest Lp(a) levels are seen in non-Hispanic whites, higher in Hispanics, and highest in blacks [11]. Of note, however, most studies and metaanalyses indicate an increased CVD risk with Lp(a) levels as low as > 25–30 mg/dL [5].
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