Abstract
BackgroundAntiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with poor viral suppression could explain their non-adherence to long term ART.MethodsThis qualitative cross-sectional study was conducted in Uganda between September 2015 and April 2016. Thirty individuals on ART for 5 years or more (10 on first line and 20 on second line), with poor viral suppression, were randomly selected from a cohort of people living with HIV on ART. In-depth interviews about ART; awareness, adherence counselling, obstacles to daily adherence and regimen switches were conducted. Emerging themes from the interviews transcripts and field notes were identified and thematic content analysis done. Participants’ consent, compensation, confidentiality and study ethical approvals were ensured.ResultsWe found that poor adherence to long term ART was due to: travel for work or social activities, stigma, receiving little or no continuous ART adherence education, alcohol consumption and use of alternative ‘HIV cure’ medicines. Other reasons included; ART side effects, treatment fatigue, belief that long-term ART or God can ‘cure HIV’, and food security.ConclusionsAchieving optimal ART benefits requires continuous provision of ART adherence education to individuals on long term ART. This helps them overcome the challenges related to living with HIV: worries of food insecurity, alcohol misuse, economic hardship, and beliefs in HIV cures and use of unproven alternative HIV treatments. People living with HIV who travel require adherence support and larger quantities of ART refills to cover their time away.
Highlights
Antiretroviral therapy (ART) use in HIV management has reduced morbidity and mortality among people living with HIV
In this paper we examine the experiences of people living with HIV with poor viral suppression and how different circumstances could explain their non-adherence to long term ART
Study design and settings This cross sectional qualitative study was nested in the Complications of Long-term Antiretroviral Therapy (CoLTART) cohort study that was conducted in Kalungu and Wakiso districts in Uganda
Summary
Antiretroviral therapy (ART) use in HIV management has reduced morbidity and mortality among people living with HIV. ART improves life expectancy and quality of life for people living with HIV, while the resultant viral suppression reduces the HIV transmission risk [1,2,3,4,5]. Adherence remains a challenge for many people living with HIV [1, 13,14,15]. Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with poor viral suppression could explain their non-adherence to long term ART
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