Abstract
What Can Systems Theory of Networks Offer to Biology?
Highlights
Cellular differentiation is the process via which the nucleus achieves a new function
The basic question is how network geometry with a particular initial configuration evolves toward a specific cell type with its own unique configuration and how essential features of the network evolve with this geometry
We pose that the essential features of the network that evolve to allow for efficient reprogramming fall in the realm of control theory
Summary
Cellular differentiation is the process via which the nucleus achieves a new function. The relationship between nuclear form and function will be critical to understanding the dynamics of the nucleus during cell differentiation [5,6]. We first define form as a geometric network that reflects the physical configuration of chromosomes in the interphase nucleus and function as the transcriptional network.
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