Abstract
“Bad men need nothing more to compass their ends, than that good men should look on and do nothing,” said the British philosopher John Stuart Mill in his 1876 address to St Andrews University. Not in the moral remit, but in the physiological context, astrocytes certainly do more than “look on and do nothing”. They are responsible for metabolic coupling with neurons, which ensures ionic, neurotransmitter, pH, redox, and bioenergetic homoeostasis, and actively meets neuronal demands to achieve homoeostatic regulation.
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